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# Training Material

## Degradation Kinetics Training Material

Two training courses have been conducted by the FOCUS Work Group on Degradation Kinetics.

One course occurred in **Jan. 2005 in Brussels** and was a two day session for representatives of the EU member states. The other course was given in **Washington in January 2006** and consisted of a session for the U.S. EPA and Canadian PMRA and the next day a session for industry scientists. All training sessions were split into about equal periods of hand-on sessions and lectures.

The main difference between the two courses was the length of the course and the model used as an example. In the course in Brussels ModelMaker and an Excel spreadsheet was used and quite a bit of time was used to introduce the participants to the use of both of these software tools, resulting in a two day course. In the course in Washington only one day was available for each session so the training course only used the software tool KinGUI recently developed by industry which included the needed functions of both ModelMaker and the Excel spreadsheet into a single software package. Some topics such as harmonisation of data from field studies and reporting were also not covered in Washington.

In order to fully utilize the training material you will need to obtain a copy of the software used for the training exercises. ModelMaker is available commercially as described in the final report of the FOCUS Work Group on Degradation Kinetics (available on this website), the Excel spreadsheet is available on this website, and KinGUI is available free of charge from Dieter Schafer at dieter.schaefer@bayercropscience.com. Please note that FOCUS does not endorse either ModelMaker or KinGUI. The recommendations of the work group are independent of specific software packages. The training material also includes spreadsheets developed by the work group. While these spreadsheets are similar or identical to the official versions available in the software section of the web site, the spreadsheets in the training material should be used only for training since they will not be updated as changes are made to the official versions. The official versions of the spreadsheets should be used for all regulatory applications.

#### Training Materials from Brussels Training Session, January 2005

*Required software for practical exercises: ModelMaker and Excel Spreadsheet*

- 1.1 Introduction (Jos Boesten)
- Presentation: 1_1 Introduction.ppt

- 1.2 Remit (Russell Jones)
- Presentation: 1_2 Remit.ppt

- 1.3 Regulatory uses of degradation endpoints (Sylvia Karlsson)
- Presentation: 1.3 regulatory use.ppt

- 1.4 Kinetic Models (Guy Soulas)
- Presentation: 1.4 kin_models(rev2).ppt

- 1.5 Data Handling (Sabine Beulke)
- Presentation: 1_5_Data handling.ppt
- Excel Worksheet required for practical exercises:
- Practical Exercise:
- Solutions to Practical Exercises:

- 1.6 Introduction to ModelMaker (Sabine Beulke)
- Presentation: 1_6_1 Introduction to ModelMaker.ppt
- Practical Exercises:
- Model construction: 1_6_2_parent_practical_model_construction.doc
- Curve fitting and parameter estimation for example 1: 1_6_3_Parent_practical_fitting_example1.doc
- Curve fitting and parameter estimation for example 2: 1_6_4_Parent_practical_fitting_example2.doc

- Solutions to Practical Exercises:
- Curve fitting and parameter estimation for example 1: 1_6_3_Parent_practical_fitting_example1_solution.doc
- Curve fitting and parameter estimation for example 2: 1_6_4_Parent_practical_fitting_example2_solution.doc

- Electronic Files for Practical Exercises:
- Model construction:
- MOD file: parent_only.mod

- Spreadsheet for Calculating DT50 and DT90 for DFOP kinetics:

- Model construction:

- 1.7 Normalisation of Field Half-Lives (Ian Hardy)
- Presentation: 1.7 Normalization of Field Half-Lives.ppt

- 1.8 Parameter Optimisation (Sabine Beulke)
- Presentation: 1_8_Parameter optimisation.ppt

- 1.9 Adjustments for Software Settings (Jeremy Dyson)
- Presentation: 1.9 software adjustment.ppt

- 1.10 Recommended Procedures for Deriving Endpoints for Parent Compounds (Ralph Warren)
- Presentation: 1_10_Chapter_7_presentation.ppt

- 1.11 Practical Exercises for Deriving Endpoints for Parent Compounds (Ralph Warren)
- Presentation and Exercises: 1_11_Chapter_7_practical.ppt
- Solutions to Practical Exercises: 1_11_Chapter_7_practical_answers.ppt
- Excel Spreadsheets required:

- 2.1 Theory for Metabolites (Karin Aden)
- Presentation: 2_1_Theory Metabolites.ppt

- 2.2 Fitting of Metabolites (Claude Beigel)

An error in the input data for Metabolite 2 of Example 1 in the Brussels session has been corrected- Presentation and Exercises: 2.2_metabolite curve fitting.ppt
- Input Data: 2.2_metabolites examples input.xls
- Electronic Files for Practical Exercises:
- Example 1:
- Parent: 2.2_Example 1_parent.mod
- Individual rates: 2.2_Example 1_individual rates.mod

- Example 2:
- Parent FOMC: 2.2_Example 2_parentFOMC.mod
- Parent DFOP: 2.2_Example 2_parentDFOP.mod

- Example 1:

- 2.3 Goodness of Fit for Metabolites (Claude Beigel)
- Presentation and Exercises: 2.3_metabolite goodness of fit.ppt
- Input Data: 2.2_metabolites examples input.xls
- Electronic Files for Practical Exercises:
- Excel Spreadsheets required:

- 2.4 Results of Metabolite Practical Exercises (Claude Beigel)
- Presentation: 2.4_metabolite results.ppt
- Detailed Results:
- Electronic Files for Practical Exercises:

- 2.5 Fitting with Berkeley Madonna (Ton van der Linden)
- Presentation: 2.5_Demonstration of fitting with Berkeley Madonna_1.ppt

- 2.6 Fitting with MATLAB (Dieter Schäfer)
- Presentation: 2_6_MATLAB.ppt

- 2.7 Reporting Guidelines (Ton van der Linden)
- Presentation: 2.7_degkin-reporting.ppt

- 2.8 Water-sediment Studies (Jeremy Dyson)
- Presentation: 2.8 water-sediment studies.ppt

#### Training Materials from Washington Training Session, January 2006

*Required software for practical exercises: KinGUI*

- 01 Introduction (Jos Boesten)
- Presentation: 01-intro EPA 2006.ppt 02

- 02 Remit (Russell Jones)
- Presentation: 02-workgroupremit.ppt

- 03 Kinetic Models (Jeremy Dyson)
- Presentation: 03-Kinetic Models.ppt

- 04 Parameter Optimisation (Sabine Beulke)
- Presentation: 04-Parameter optimisation.ppt

- 05 Introduction to KinGUI software (Dieter Schäfer)
- Presentation: 05-KinGUIsoftwaretool.ppt

- 06 Data Handling (Sabine Beulke)
- Presentation:06-Data handling.ppt
- Practical Exercises: Data handling_practical.doc
- Solutions to Practical Exercises: handling_practical_solutions.doc
- Data files:

- 08 Recommended Procedures for Deriving Endpoints for Parent Compounds (Ralph Warren)
- Presentation: 08-Parent fitting presentation RLW.ppt
- Practical Exercises: Parent only fitting practical.doc
- Solutions to Practical Exercises: Parent only fitting practical answers.doc
- Data files:

- 09 Fitting of Metabolites (Claude Beigel)
- Presentation: 09-Theory metabolites.ppt
- Practical Exercises: Metabolites fitting practical.doc
- Solutions to Practical Exercises: Metabolites fitting practical answers.doc
- Data files:

- 10 Fitting with ModelMaker (Claude Beigel)
- Presentation: 10-Software tools_ModelMaker demo.ppt

- 11 Water-sediment Studies (Jeremy Dyson)
- Presentation: 11 Water-sediment studies.ppt